Unfortunately, acne tends to get worse during pregnancy. Blame your hormones and you’re beautiful, oily glow of pregnancy. Still, there are a few things that you can do. It is safe to wash your face with benzoyl peroxide during pregnancy. Benzoyl peroxide is the common ingredient of most over-the-counter acne remedies. Check the label.
If you wash your face at night and then go and lay down on your pillow from last night, you may find that you have re-contaminated your face with last nights oils and bacteria. One evidence-based trick is to place a fresh clean towelette over your pillow each night that you removed in the morning. This towelette can collect the new night skin oils and bacteria and not allow them to saturate into your pillow and pillowcase. Just change it each night.
Many other acne treatments are not safe during pregnancy. Ask your doctor before trying any other remedies.